Jan Vertonghen’s stoppage-time goal continued Tottenham’s turnaround under Jose Mourinho.
Spurs moved up to fifth with a 2-1 win to end the hosts’ unbeaten run.
Mourinho’s men were largely outplayed at Molineux but were ruthless with their chances to inflict Wolves’ first league defeat in 12 games.
Adama Traore’s spectacular strike had cancelled out Lucas Moura’s early opener before Vertonghen stooped to guide home Christan Eriksen’s corner.
Spurs can now move into the top four before Christmas if they beat Chelsea at home next weekend.
That speaks volumes for the impact Mourinho has made in less than a month in charge as Tottenham trailed Chelsea and the top four by 12 points when he was appointed.
Wolves drop to eighth as their longest unbeaten run in the top flight since 1962 came to an end, but there was little more Nuno Espirito Santo’s men could have done to at least avoid defeat.